This course focuses on synthesis, structure, and properties of nanomaterials. It begins with the introduction to the fundamental principles for understanding the size-dependent properties of materials that emerge at the nanoscale. It surveys a number of experimental techniques that can be utilized for observing and analyzing nanostructures, including X-ray techniques, scanning probe microscopy, and electron microscopy. It further details how strategies for synthesis, surface chemistry, and self-assembly can be utilized to control and tailor structure and properties of nanomaterials. Finally, the course highlights the applications of nanomaterials in chemical sensing, disease diagnosis and treatment, energy conversion and storage, and information storage. The class features a Wikipedia editing project, and visiting lectures highlighting modern technological applications of nanomaterials from PhD-level guest speakers.